Solid-phase synthesis of PEGylated lipopeptides using click chemistry.
نویسندگان
چکیده
A versatile methodology for efficient synthesis of PEGylated lipopeptides via CuAAC "Click" conjugation between alkyne-bearing solid-supported lipopeptides and azido-functionalized PEGs is described. This new and very robust method offers a unique platform for synthesizing PEGylated lipopeptides with a high level of complexity. These molecules, obtained in a single purification step, are ideally suited for functionalization of solid-supported lipid bilayers and liposomal drug delivery systems and are particularly valuable in enzyme activation strategies.
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ورودعنوان ژورنال:
- Bioconjugate chemistry
دوره 21 5 شماره
صفحات -
تاریخ انتشار 2010